Dataset | Set_04_transDMpreB_versus_DMpreB.phenotype_transDMpreB_versus_DMpreB.cls #transDMpreB_versus_DMpreB.phenotype_transDMpreB_versus_DMpreB.cls #transDMpreB_versus_DMpreB_repos |
Phenotype | phenotype_transDMpreB_versus_DMpreB.cls#transDMpreB_versus_DMpreB_repos |
Upregulated in class | transDMpreB |
GeneSet | INOH_POSITIVE REGULATION OF (TRANSCRIPTION OF SOCS BY STAT DIMER) IN JAK STAT PATHWAY |
Enrichment Score (ES) | 0.58812934 |
Normalized Enrichment Score (NES) | 1.669299 |
Nominal p-value | 0.0 |
FDR q-value | 0.1370043 |
FWER p-Value | 0.517 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | MAP3K14 | 11998 | 27 | 2.958 | 0.0400 | Yes | ||
2 | MAP4K2 | 6457 | 72 | 2.603 | 0.0741 | Yes | ||
3 | BTK | 24061 | 118 | 2.378 | 0.1050 | Yes | ||
4 | MAP3K11 | 11163 | 275 | 2.001 | 0.1246 | Yes | ||
5 | STAT3 | 5525 9906 | 302 | 1.915 | 0.1500 | Yes | ||
6 | IRAK1 | 4916 | 322 | 1.872 | 0.1752 | Yes | ||
7 | MAPK14 | 23313 | 334 | 1.857 | 0.2006 | Yes | ||
8 | PAK4 | 17909 | 396 | 1.777 | 0.2222 | Yes | ||
9 | MAP3K1 | 21348 | 512 | 1.620 | 0.2387 | Yes | ||
10 | SYK | 21636 | 513 | 1.619 | 0.2614 | Yes | ||
11 | IKBKB | 4907 | 558 | 1.550 | 0.2807 | Yes | ||
12 | TYK2 | 12058 19215 | 563 | 1.543 | 0.3021 | Yes | ||
13 | PRKCD | 21897 | 716 | 1.338 | 0.3126 | Yes | ||
14 | RPS6KA1 | 15725 | 736 | 1.314 | 0.3300 | Yes | ||
15 | MAP2K1 | 19082 | 767 | 1.285 | 0.3464 | Yes | ||
16 | MAP3K3 | 20626 | 808 | 1.254 | 0.3618 | Yes | ||
17 | MKNK2 | 3299 9392 | 809 | 1.250 | 0.3793 | Yes | ||
18 | CAMK2G | 21905 | 866 | 1.191 | 0.3930 | Yes | ||
19 | STAT2 | 19840 | 885 | 1.179 | 0.4085 | Yes | ||
20 | CSK | 8805 | 940 | 1.117 | 0.4213 | Yes | ||
21 | MAPK3 | 6458 11170 | 961 | 1.090 | 0.4354 | Yes | ||
22 | MAP3K7 | 16255 | 1018 | 1.035 | 0.4469 | Yes | ||
23 | RAF1 | 17035 | 1186 | 0.942 | 0.4511 | Yes | ||
24 | JAK1 | 15827 | 1249 | 0.894 | 0.4603 | Yes | ||
25 | MKNK1 | 2504 | 1254 | 0.891 | 0.4725 | Yes | ||
26 | MAP3K8 | 23495 | 1281 | 0.872 | 0.4833 | Yes | ||
27 | JAK3 | 9198 4936 | 1299 | 0.858 | 0.4944 | Yes | ||
28 | CHUK | 23665 | 1310 | 0.853 | 0.5058 | Yes | ||
29 | LTK | 14467 | 1380 | 0.814 | 0.5135 | Yes | ||
30 | TEC | 16514 | 1394 | 0.805 | 0.5241 | Yes | ||
31 | CDK5 | 16591 | 1415 | 0.791 | 0.5341 | Yes | ||
32 | PTK2 | 22271 | 1498 | 0.741 | 0.5400 | Yes | ||
33 | NLK | 5179 5178 | 1529 | 0.723 | 0.5485 | Yes | ||
34 | PDPK1 | 23097 | 1610 | 0.675 | 0.5537 | Yes | ||
35 | MAP2K2 | 19933 | 1669 | 0.648 | 0.5596 | Yes | ||
36 | MAP2K3 | 20856 | 1692 | 0.634 | 0.5673 | Yes | ||
37 | ARAF | 24367 | 1729 | 0.613 | 0.5739 | Yes | ||
38 | CDK2 | 3438 3373 19592 3322 | 1865 | 0.529 | 0.5740 | Yes | ||
39 | PRKCZ | 5260 | 1877 | 0.520 | 0.5807 | Yes | ||
40 | PLK3 | 15790 | 1938 | 0.487 | 0.5843 | Yes | ||
41 | STAT5A | 20664 | 2075 | 0.430 | 0.5830 | Yes | ||
42 | PTK2B | 21776 | 2197 | 0.385 | 0.5818 | Yes | ||
43 | MAP4K3 | 22887 | 2224 | 0.377 | 0.5857 | Yes | ||
44 | MAP3K2 | 11165 | 2345 | 0.340 | 0.5840 | Yes | ||
45 | GRK6 | 6449 | 2385 | 0.327 | 0.5864 | Yes | ||
46 | ACVR2B | 19276 | 2436 | 0.310 | 0.5881 | Yes | ||
47 | CAMK2A | 2024 23541 1980 | 2511 | 0.290 | 0.5881 | Yes | ||
48 | MAPK12 | 2182 2215 22164 | 2721 | 0.246 | 0.5803 | No | ||
49 | MAP3K12 | 6454 11164 | 2832 | 0.229 | 0.5775 | No | ||
50 | ZAP70 | 14271 4042 | 2886 | 0.219 | 0.5777 | No | ||
51 | PDGFRB | 23539 | 2909 | 0.214 | 0.5795 | No | ||
52 | PRKAR2B | 5288 2107 | 2970 | 0.205 | 0.5792 | No | ||
53 | MAP3K5 | 20079 11166 | 3069 | 0.191 | 0.5765 | No | ||
54 | RIPK1 | 5381 | 3213 | 0.170 | 0.5712 | No | ||
55 | CSNK1E | 6570 2211 11332 | 3242 | 0.166 | 0.5720 | No | ||
56 | PAK1 | 9527 | 3601 | 0.130 | 0.5544 | No | ||
57 | JAK2 | 23893 9197 3706 | 3607 | 0.130 | 0.5560 | No | ||
58 | PLK1 | 9590 5266 | 3640 | 0.127 | 0.5560 | No | ||
59 | RIPK2 | 2528 15935 | 3734 | 0.119 | 0.5527 | No | ||
60 | IKBKG | 2570 2562 4908 | 3736 | 0.119 | 0.5543 | No | ||
61 | MAPK9 | 1233 20903 1383 | 4094 | 0.096 | 0.5363 | No | ||
62 | KIT | 16823 | 4135 | 0.093 | 0.5355 | No | ||
63 | CDK6 | 16600 | 4318 | 0.083 | 0.5268 | No | ||
64 | MAPK13 | 23314 | 4397 | 0.080 | 0.5237 | No | ||
65 | RPS6KA2 | 9759 9758 | 5200 | 0.053 | 0.4811 | No | ||
66 | MAPK7 | 1381 20414 | 5307 | 0.050 | 0.4760 | No | ||
67 | PRKAR2A | 5287 | 5355 | 0.049 | 0.4742 | No | ||
68 | FGFR1 | 3789 8968 | 5469 | 0.047 | 0.4687 | No | ||
69 | FGFR2 | 1917 4722 1119 | 5517 | 0.046 | 0.4668 | No | ||
70 | STAT4 | 14251 9907 | 5526 | 0.045 | 0.4670 | No | ||
71 | BMPR1A | 8660 4450 | 5558 | 0.045 | 0.4660 | No | ||
72 | ALK | 8574 | 5658 | 0.042 | 0.4612 | No | ||
73 | BMPR2 | 14241 4081 | 5692 | 0.042 | 0.4600 | No | ||
74 | PRKG1 | 5289 | 5722 | 0.041 | 0.4590 | No | ||
75 | RYK | 19338 3870 | 6139 | 0.034 | 0.4370 | No | ||
76 | MAPK11 | 2264 9618 22163 | 6170 | 0.033 | 0.4358 | No | ||
77 | MAPKAPK5 | 16387 | 6436 | 0.029 | 0.4219 | No | ||
78 | FGFR3 | 8969 3566 | 7141 | 0.018 | 0.3841 | No | ||
79 | MOS | 16254 | 7388 | 0.015 | 0.3710 | No | ||
80 | ACVRL1 | 22354 | 7450 | 0.014 | 0.3679 | No | ||
81 | ITK | 4934 | 8021 | 0.007 | 0.3371 | No | ||
82 | ACVR2A | 8542 | 8040 | 0.007 | 0.3363 | No | ||
83 | PRKCE | 9575 | 9170 | -0.006 | 0.2753 | No | ||
84 | CDK7 | 21365 | 9267 | -0.007 | 0.2702 | No | ||
85 | PRKCQ | 2873 2831 | 9311 | -0.008 | 0.2680 | No | ||
86 | RPS6KB2 | 7198 | 9416 | -0.009 | 0.2625 | No | ||
87 | PRKCI | 9576 | 9605 | -0.012 | 0.2525 | No | ||
88 | AKT1 | 8568 | 9662 | -0.013 | 0.2496 | No | ||
89 | BMPR1B | 8661 15152 4451 | 9935 | -0.016 | 0.2351 | No | ||
90 | NGFR | 5174 | 10094 | -0.018 | 0.2268 | No | ||
91 | TGFBR1 | 16213 10165 5745 | 10621 | -0.025 | 0.1987 | No | ||
92 | PRKCH | 21246 | 10685 | -0.026 | 0.1957 | No | ||
93 | SRC | 5507 | 10688 | -0.026 | 0.1959 | No | ||
94 | FLT4 | 20904 1461 | 10833 | -0.028 | 0.1885 | No | ||
95 | PDGFRA | 16824 | 10927 | -0.030 | 0.1839 | No | ||
96 | AKT2 | 4365 4366 | 11247 | -0.035 | 0.1672 | No | ||
97 | IRAK4 | 22379 11185 | 11420 | -0.038 | 0.1584 | No | ||
98 | KDR | 16509 | 11588 | -0.041 | 0.1499 | No | ||
99 | STAT5B | 20222 | 11863 | -0.046 | 0.1357 | No | ||
100 | EGFR | 1329 20944 | 12205 | -0.054 | 0.1181 | No | ||
101 | PAK3 | 9528 | 12282 | -0.056 | 0.1147 | No | ||
102 | IGF1R | 9157 | 12594 | -0.064 | 0.0988 | No | ||
103 | FLT1 | 3483 16287 | 12672 | -0.067 | 0.0956 | No | ||
104 | MAPKAPK2 | 13838 | 12872 | -0.073 | 0.0858 | No | ||
105 | MAPK10 | 11169 | 13511 | -0.099 | 0.0527 | No | ||
106 | PRKACA | 18549 3844 | 13814 | -0.116 | 0.0380 | No | ||
107 | WEE1 | 18127 | 13987 | -0.127 | 0.0305 | No | ||
108 | INSR | 18950 | 14023 | -0.129 | 0.0304 | No | ||
109 | PRKCA | 20174 | 14071 | -0.131 | 0.0297 | No | ||
110 | MET | 17520 | 14073 | -0.132 | 0.0315 | No | ||
111 | IKBKE | 67 | 14176 | -0.139 | 0.0279 | No | ||
112 | TGFBR2 | 2994 3001 10167 | 14270 | -0.147 | 0.0249 | No | ||
113 | FGFR4 | 3226 | 14308 | -0.151 | 0.0250 | No | ||
114 | PRKG2 | 74 | 14506 | -0.170 | 0.0168 | No | ||
115 | MAP2K6 | 20614 1414 | 14512 | -0.170 | 0.0189 | No | ||
116 | PRKAR1B | 16320 | 14559 | -0.175 | 0.0188 | No | ||
117 | CAMK2B | 20536 | 14588 | -0.178 | 0.0198 | No | ||
118 | GSK3B | 22761 | 14988 | -0.227 | 0.0014 | No | ||
119 | RPS6KA3 | 8490 | 15832 | -0.385 | -0.0388 | No | ||
120 | FYN | 3375 3395 20052 | 15886 | -0.398 | -0.0361 | No | ||
121 | MNAT1 | 9396 2161 | 15949 | -0.416 | -0.0336 | No | ||
122 | STAT1 | 3936 5524 | 15957 | -0.419 | -0.0281 | No | ||
123 | MAPK8 | 6459 | 16644 | -0.646 | -0.0562 | No | ||
124 | MAP2K4 | 20405 | 16860 | -0.753 | -0.0573 | No | ||
125 | PAK2 | 10310 5875 | 16924 | -0.783 | -0.0497 | No | ||
126 | ACVR1 | 4334 | 17118 | -0.886 | -0.0477 | No | ||
127 | CCNH | 7322 | 17501 | -1.064 | -0.0535 | No | ||
128 | AKT3 | 13739 982 | 17683 | -1.172 | -0.0468 | No | ||
129 | LCK | 15746 | 17991 | -1.398 | -0.0439 | No | ||
130 | CDK4 | 3424 19859 | 18093 | -1.498 | -0.0283 | No | ||
131 | GFRA1 | 9015 | 18358 | -1.890 | -0.0161 | No | ||
132 | RIPK3 | 21817 | 18461 | -2.145 | 0.0084 | No |